NUCLEIC ACID NANOPARTICLES, PHARMACEUTICAL COMPOSITION COMPRISING SAME, DRUG COMPRISING DOXORUBICIN AND PREPARATION METHOD THEREFOR

摘要

Disclosed are nucleic acid nanoparticles, a pharmaceutical composition comprising the same, a drug comprising doxorubicin and a preparation method thereof. The nucleic acid nanoparticles have a nucleic acid structural domain, the nucleic acid structural domain includes a sequence a, a sequence b and a sequence c; the sequence a includes a sequence a1 or a sequence obtained by insertion, deletion or substitution of at least one base in the sequence a1, the sequence b includes a sequence b1 or a sequence obtained by insertion, deletion or substitution of at least one base in the sequence b1, and the sequence c includes a sequence d or a sequence obtained by insertion, deletion or substitution of at least one base in the sequence d. The nucleic acid nanoparticles are capable of, by means of including the three sequences described above or variant sequences thereof, not only self-assembling to form the nucleic acid structural domain, but also serving as a carrier. While served as the carrier, the nucleic acid nanoparticles are not only capable of loading and delivering nucleic acid drugs, but are also suitable for loading and delivering other biologically active substances such as chemical drugs.