PREPARATION AND USE OF NANOMATERIAL SPECIFICALLY ACTIVATING IMMUNE SYSTEM

摘要

Disclosed are a nanoparticle that can be used for tumor photothermal therapy and medical imaging, and a method for preparing a polyethylene glycol-IR-797-DC cell membrane nanoparticle (DC-NP), the method comprising wrapping an antigen-loaded DC cell membrane on a particle skeleton formed by phospholipid polyethylene glycol amino (DSPE-PEG) and IR-797 triggered by near-infrared light, thereby forming a polyethylene glycol-IR-797-DC cell membrane nanoparticle (DC-NP) that promotes the enrichment, proliferation, activation and near-infrared light absorption of T cells at a tumor site. The method synergistically improves the effect of low-temperature photothermal anti-tumor therapy by means of enhancing the immune response of a body.