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BASE EDITORS WITH DIVERSIFIED TARGETING SCOPE
BASE EDITORS WITH DIVERSIFIED TARGETING SCOPE
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机译:具有多元化定位范围的基础编辑器
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摘要
The present disclosure provides improved adenosine base editors (ABE) that have an expanded range of PAM sequence recognition capability (i.e., recognition of non-canonical 5̕ -NGG-3̕ PAM sequence). In addition, the present disclosure provides improved cytidine base editors (CBE) and adenosine base editors (ABE) comprising circular permutant variants of Cas9 (CP-Cas9) with an increased window of base editing within the protospacer sequence (e.g., from about 4-5 nucleotides to up to about 8-9 nucleotides) and even outside of the protospacer sequence.
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