SIRNA AND NANO DELIVERY SYSTEM CAPABLE OF SILENCING PCSK9 PROTEIN, AND APPLICATION OF NANO DELIVERY SYSTEM

摘要

siRNA capable of silencing a Pcsk9 protein. A sense strand amino acid sequence of the siRNA is 5'-UUCCGAAUAAACUCCAGGC-3', and an anti-sense strand amino acid sequence is 5'-GCCUGGAGUUUAUUCGGAA-3'. Further provided are a nano delivery system capable of silencing the Pcsk9 protein, a preparation method therefor, and an application thereof. The method has a higher transfection effect, can maintain long-term action, has a better treatment effect of reducing blood lipid, and is applicable to gene therapy for reducing blood lipid.