6-(4-amino-3-methyl-2-oxa-8-azaspiro4.5decan-8-yl)-3-(2,3-dichlorophenyl)- as a PTPN11 (SHP2) inhibitor for cancer treatment 2-methylpyrimidine-4(3H)-one derivatives and related compounds

摘要

The present invention relates to 6-(N-substituted)-3-aryl-2-methylpyrimidin-4(3H)-one useful as an inhibitor of PTPN11 (SHP2) for the treatment or prevention of cancer and PTP-mediated diseases. It relates to compounds.