Solanum dubium seeds and honey (extracted from bee hives in Acacia tree populated area) combination for treatment of asthma and bronchial asthma

摘要

An herbal remedy to asthma comprising a weighed proportional mixture of Sunnut honey and powder of ground seeds of Solarium dubium. Separation and isolation of active compounds from the methanolic extract of combination was carried out using bioassay-guided fractionation. The in-vivo experiments were implemented to assess the toxicological study of the crude and methanolic extracts of the combination, honey and the seeds. The results revealed that there is no acute or sub-chronic toxicity displayed by the different concentrations of the extracts. The method of Carrageenan induced paw edema in Wister Rats was done to evaluate the anti-inflammatory effects of aqueous crude extract of S. dubium seeds, honey and combination. The results showed that all ingredients were found to have a significant anti inflammatory activity on paw edema volume. Also the result of methanolic extracts showed a significant inhibition of inflammation, As a clinical trial for the combined ingredients, twenty five patients medically diagnosed as asthmatic were randomly selected and enrolled in the study; none of them is currently using anti-asthmatic drugs. Signs of asthma disappeared in the treated patients.