SYSTEM AND METHOD FOR RISK ASSESSMENT OF MULTIPLE SCLEROSIS

摘要

Multiple sclerosis (MS) is a neurodegenerative autoimmune disease affecting brain and the spinal cord which results in distorted communication between brain and rest of the body. It is necessary to assess the risk of MS at the earliest. A system and method for diagnosis and risk assessment of an individual for multiple sclerosis has been provided. The system is using a non-invasive method for risk assessment through prediction of metabolic potential of the bacteria residing in gastrointestinal tract of the individual. The system is configured to calculate a score, which is evaluated from the gut bacterial taxonomic abundance profile, indicative of its metabolic potential for production of a particular neuroactive compound. The score is subsequently used to predict the risk of the individual for MS. The present disclosure also provides microbiome based therapeutic approaches that can potentially minimize the side effects through maintaining the healthy cohort of bacteria in gut.