Multiple specificity Fab fusion proteins and usage

摘要

Multiple specificity Fab fusion protein and its use.The present invention relates to a multiple specificity Fab fusion protein (MSFP) containing Fab fragments of an antibody that fused both of the N-terminus into a fusion portion.MSFP contains Fab fragments presenting a significantly reduced binding ability to Fab targets of Fab fragments.The binding of fab to its target is restored when the MSFP aggregates at the cell surface via the binding to their target in the fusion portion.In particular, if the binding of fab to its target is reduced or the binding of the fusion portion is not present in the native state of the cell surface, the benefit of reducing side effects can be obtained, and the pharmacological effects of the desired selectivity and specificity are Controlled modes.No selection