THERAPEUTIC AGENTS FOR REDUCING PARATHYROID HORMONE LEVELS

摘要

Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X₁ - X₂ - X₃ - X₄ - X₅ - X₆ - X₇, wherein the X₁ subunit comprises a thiol-containing moiety and the distribution of charge on the X₂-X₇ subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.