FUSION PROTEIN CONTAINING HUMAN INTERLEUKIN-10 AND FC FRAGMENT AND MEDICAL USE THEREOF

摘要

Provided are a fusion protein and the medical use thereof. The fusion protein is prepared by fusing a human interleukin-10 (IL-10) with an Fc fragment of an immunoglobulin IgG via a linker peptide. The Fc fragment is the Fc fragment of human IgG1, human IgG2 and human IgG4, and the human interleukin-10 comprises the amino acid sequence as shown in SEQ ID NO: 1. The fusion protein can be used for the treatment of immunological diseases and cancers, and prolongs the in vivo half-life of human IL-10 and increases the in vivo stability of human IL-10.