FUSION PROTEINS FROM FRAGMENTS OF HUMAN PROTEINS FOR OBTAINING COMPOSITIONS OF MULTIPLE MULTIMERIZED FC IMMUNOGLOBULINS WITH IMPROVED BINDING WITH THE FC RECEPTOR

摘要

The present invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. The invention involves fusion proteins that bind to FcγRs and complement and that are useful in the treatment and prevention of disease.