首页>
外国专利>
ANTIBODY COMPOSITIONS COMPRISING FC MUTATIONS AND SITE-SPECIFIC CONJUGATION PROPERTIES
ANTIBODY COMPOSITIONS COMPRISING FC MUTATIONS AND SITE-SPECIFIC CONJUGATION PROPERTIES
展开▼
机译:包含Fc突变和位点特异性缀合性质的抗体组合物
展开▼
页面导航
摘要
著录项
相似文献
摘要
Antibodies that bind Her2, EGFR, Trop2, CDH3 or other TAAs containing a triple mutation at L234A, L235A, and L328C and methods of making such triple mutated antibodies are disclosed herein. Consequently, the triple mutated antibodies contain a modified effector function through Fc silencing and are capable of site-specific conjugation at L328C to form an antibody-drug-conjugate (ADC) which can be administered to patients and provide a method of treating cancer, immunological and neurological disorders.
展开▼