A cell death inducer for cells having a BRAF gene mutation, a growth inhibitor of the cells, and a pharmaceutical composition for treating a disease caused by abnormal growth of the cells.

摘要

PROBLEM TO BE SOLVED: To provide an agent having a cell death-inducing action and / or a cell growth-suppressing action on a cell having a mutation in the BRAF gene, and to provide a pharmaceutical composition for treating a disease caused by abnormal cell growth. Furthermore, a method for screening a cell death inducer and / or a cell growth inhibitor is provided. A pharmaceutical composition for treating a disease caused by abnormal growth of cells having a mutation in the BRAF gene, including RNAi molecule, ribozyme, antisense nucleic acid, DNA / RNA chimeric polynucleotide, and at least one of them. A pharmaceutical composition comprising a drug that suppresses the production of GST-π, which is selected from the group consisting of vectors expressing the above, and which is administered simultaneously with or separately from a BRAF inhibitor. [Selection diagram] Fig. 1