CO-DELIVERY OF TGF-β SIRNA AND PDL1 SIRNA TO TREAT CANCER

摘要

Compositions containing an anti-TGF-β siRNA molecule and an anti-PDL1 siRNA molecule are provided. Methods of using these compositions to treat cancer also are provided. The anti-TGF-β siRNA molecule may contain an anti-TGF-βΙ siRNA molecule. One or both molecules may comprise an oligonucleotide with a length of 19 base pairs to 25 base pairs, and one or both may be chemically modified to increase their stability.