(S)-(2R, 3R, 11bR) -3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido 2,1-a isoquinoline-2- Synthetic method for the preparation of yl2-amino-3-methylbutanoatedi (4-methylbenzenesulfonate)

摘要

PROBLEM TO BE SOLVED: To provide a synthetic method for preparing a compound. SOLUTION: (S)-(2R, 3R, 11bR) -3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido [2,1-a] A process for preparing isoquinoline-2-yl 2-amino-3-methylbutanoatedi (4-methylbenzenesulfonate) or a solvate, hydrate or polymorph thereof is provided herein. To. In other embodiments, those methods have a purity greater than 95% (S)-(2R, 3R, 11bR) -3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b. -Hexahydro-1H-pyrido [2,1-a] isoquinoline-2-yl 2-amino-3-methylbutanoatedi (4-methylbenzenesulfonate) is provided. [Selection diagram] None