Antibody inducing immunotolerance, induced lymphocytes and therapeutic agents for cell therapy using induced lymphocytes

摘要

The present disclosure provides antibodies for inducing immunotolerance, induced lymphocytes, and therapeutic methods for cell therapy using induced lymphocytes.In particular, the present disclosure provides antibodies that inhibit the interaction of CD80 and / or CD86 expressed on the cell surface of a cell and the CD28 expressed on the cell surface of other cells, and does not substantially induce cytokines induced by immunoperactivation.In certain embodiments, the Fc portion of the antibody is a portion that does not substantially produce cytokines induced by immunoactivation.