ANTIBODY CAPABLE OF INDUCING IMMUNE TOLERANCE PRODUCED USING CELL MIXTURE HAVING COMPLEXED STATE, AND INDUCED LYMPHOCYTE OR CELL THERAPEUTIC AGENT AND CELL THERAPY METHOD EACH USING INDUCED LYMPHOCYTE

摘要

The present disclosure provides a pharmaceutical composition for antigen-specific immune tolerance or immune suppression. The present disclosure provides a pharmaceutical composition comprising a CD4-positive anergy T cell and a CD8-positive anergy T cell. In some embodiments, the anergy T cell is induced by an antibody capable of inhibiting the interaction between CD80 and/or CD86 and CD28. In a specific embodiment, the pharmaceutical composition may additionally comprise a regulatory T cell (e.g., a FOXP3-positive CD4-positive CD25-positive T cell).