An antibody that induces immune tolerance using a cell mixture having a complex state, and a cell therapeutic agent and therapy using induced lymphocytes and induced lymphocytes

摘要

The present disclosure provides a pharmaceutical composition for antigen specific immunotolerance or immunosuppression.The present disclosure provides a pharmaceutical composition comprising CD4 positive Anna Ji T cells and CD8 positive Anna Ji T cells.In some embodiments, Anna T cells are induced by antibodies that can inhibit the interaction of CD80 and / or CD86 with CD28.In certain embodiments, the pharmaceutical composition may further comprise regulatory T cells (e.g., Foxp3 positive CD4 positive CD25 positive T cells).