REAGENTS AND METHODS FOR IDENTIFYING, ENRICHING, AND/OR EXPANDING ANTIGEN-SPECIFIC T CELLS

摘要

Antigen-specific T cells, including untreated T cells and including rare precursor cells, are concentrated and proliferated in culture. Enrichment and proliferation not only provide a platform for more effective immunotherapy by adoptive transfer, but also provide a platform for personalized immunotherapy by measuring T cell responsiveness with a library of candidate peptide antigens.