A gamete comprising haploid chromosome derived from a diploid somatic cell of mammal

摘要

The present invention relates to a method for producing a germ cell comprising a haploid chromosome derived from aneuploid somatic cells, and more particularly, to a woman having a mutant mitochondrial gene or having an egg production disorder, so that a woman with her own gene can have children. Reproductive cells containing haploid chromosomes derived from female aneuploid somatic cells and a method for producing the same, a method for producing an in vitro fertilized egg using the reproductive cells prepared by the above method, an in vitro fertilized egg prepared therefrom, a blastocyst and an embryonic stem cell, the in vitro It provides a cell therapy for the treatment of infertility or infertility comprising a fertilized egg, and also provides isotype embryonic stem cells using the germ cells and a method for producing the same.