Method for preparing a kind of (1R,3S)-3-amino group-1-cyclopentanol and its salt

摘要

It is a method of preparing (1R,3S )-3-amino group-1-cyclopentanol and its salts, related to the organic synthesis domain, and derived by chiral as a chiral source in the N-hydroxamic acid compound, and cyclopenta Diene and an asymmetric cyclization reaction are carried out to form two chiral centers of the target product. The N -hydroxamic acid compound can be obtained immediately by further ammonia decomposition reaction with hydroxylamine through chiral hydroxy acid salt. This design has a wide source of raw materials, can be obtained at low cost, and can effectively reduce raw material cost. This manufacturing method is reasonable in design, simple operation, mild reaction conditions, high atomic economy, and low production cost. In addition, the three-dimensional selectivity is good and the product obtained through manufacturing has high optical purity and stable quality, so it is suitable for large-scale industrial production.