Manufacturing method and intermediate for synthesizing antitumor drug niraparib

摘要

The present invention discloses a method for preparing an intermediate for synthesizing an antitumor drug niparip and an intermediate. The present invention discloses a method for preparing compound f comprising the step of obtaining compound fby cyclization reaction of compound e as shown below in a solvent, under the action of a base. The production method of the present invention has no catalytic reduction of noble metals or no catalytic coupling and chiral decomposition of noble metals, low demand for equipment, simple operation, advantageous for industrial production, and generation of waste liquids containing heavy metals and phosphorus. Is avoided, the cost is low, and the ee value of the product is high.