Manufacturing method and intermediate for synthesizing intermediate of antitumor drug nigapaprib

摘要

The present invention has disclosed a production method and an intermediate for synthesizing an intermediate for the antitumor drug niraparib. The present invention discloses a method for producing compound f, which comprises a step of subjecting compound e to a cyclization reaction shown below under the action of a base in a solvent to obtain compound f. The production method of the present invention does not require a step of reducing with a noble metal catalyst or using coupling and chiral division with a noble metal, has low requirements for equipment, is easy to operate, is advantageous for industrial production, and is a waste liquid containing heavy metals and phosphorus. Occurrence is avoided, the cost is low, and the ee value of the product is high.