A procedure for the preparation of 3-substitute pyridine. (Machine-translation by Google Translate, not legally binding)

摘要

A procedure for the preparation of 3-substituted pyridines of the formula **(See formula)** where X is hydrogen or hydroxyl; Z is - (CH2) n-, oxygen or sulfur; n is 0 or 1; and the non-phytotoxic acid addition salts thereof; said procedure being characterized by reacting a ketone of structure **(See formula)** where Z is as defined above, and 3-pyridyllithium in an inert solvent against reactants with cooling and exclusion of free oxygen, heat the reaction mixture to room temperature and extract the mixture containing the reaction product with an acid in aqueous solution; and, if desired, reduce the hydroxyl group in the product thus obtained. (Machine-translation by Google Translate, not legally binding)