Procedure for the preparation of 3-substitute 1-oxo-isoindolins and 1-oxo-isoindolines 2,3-substitute. (Machine-translation by Google Translate, not legally binding)

摘要

Procedure for the preparation of 3-substituted 1-oxo-isoindolines and 2,3-substituted 1-oxo-isoindolines, having the following formula (I) and their salts with physiologically appropriate organic and inorganic acids: **(See formula)** in which X = H, Cl, Oralkyl, CH3, OH X = H, branched or unbranched (C1-C6) alkyl, aryl alkyl, alkylcycloalkyl, heterocyclic alkyl **(See formula)** with n = 2 - 6 R1 = H, alkyl branched or not R2 = or different from R3 and alkyl the same branched or not or belonging to a heterocyclic ring Z = O, S characterized in that the substituted or unsubstituted 3-hydroxyphthalimide is condensed with amines according to formula (II): **(See formula)** in which R1, R2, R3 and Z have the meanings mentioned above, and the products thus obtained are eventually rented. (Machine-translation by Google Translate, not legally binding)