A process for the preparation of high molecular weight, water-soluble, cross-linked proteins and peptides with immunogenic properties.

摘要

A process for the preparation of water soluble proteins and peptides of high molecular weight, by coupling amino, carboxyl or hydroxyl- containing polaminocarboxylicacids with proteins or peptides. In this way strongly cross-linked products are obtained since the polyaminocarboxylic acids contain several functional groups. The products are suitable for use as antigens in immuno-therapy, or can be used for the determination of insulin and gonadotropin. The preparation of cross-linked proteins with a molecular weight of up to 250,000, which are soluble in water, formed by coupling polyaminocarboxylic acids with suitable proteins.