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2-ALLYL-2-(BETA-HYDROXYPROPYL) MALONIC ACID UREIDE IN THE TREATING OF DISORDERS DUE TO INSUFFICENT OXYGEN AND GLUCOSE UTILIZATION IN THE BRAIN CELLS
2-ALLYL-2-(BETA-HYDROXYPROPYL) MALONIC ACID UREIDE IN THE TREATING OF DISORDERS DUE TO INSUFFICENT OXYGEN AND GLUCOSE UTILIZATION IN THE BRAIN CELLS
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机译:2-烯丙基-2-(BETA-羟丙基)丙二酸脲在脑细胞氧和葡萄糖利用不足方面的疾病治疗
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摘要
The lactone of 2-allyl-2-(b -hydroxypropyl)-malonic acid ureide is prepared by the action of a base on 5-allyl-5-(b -sulphoxypropyl)-barbituric acid, prepared by reacting 5,5-diallylbarbituric acid with sulphuric acid at a temperature of up to 28 DEG C., whereby the sulphuric acid adds to the double bond of one allyl group of said diallylbarbituric acid. Therapeutic compositions which have a valuable effect upon the function of brain and heart cells, and a weak anti-convulsant action, and which may be administered orally, parenterally or rectally, contain 2-allyl-2-(b -hydroxypropyl)-malonic acid ureide as active ingredient.
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