Procedure for the preparation of a tetracycline-based medicine. (Machine-translation by Google Translate, not legally binding)

摘要

Procedure for the preparation of a medicine based on tetracyloline, whose medicine is constituted by the association of the three following constituents: tetracycline in the form of a base or non-toxic acid addition salt, with aspirin, and a complexing amine carrier. In the case of an alcohol and/or carboxylic functional group, mainly lysine and N-methyl d-glucamine in base form or non-toxic acid addition salt, the ratio aspirin: tetracycline is between 1: 1 and 2. : 1 and the amine: tetracylin ratio between 1: 5 and 4: 5, this association being presented in an effervescent form and containing for that purpose usual ingredients such as alkali or alkaline earth carbonates or bicarbonates, citric acid, and eventually glycine, sweeteners, perfumes and dyes in the proportions known in the specialty, if necessary vitamin c in the ratio of 1: 5 to 2: 1 in relation to aspirin, characterized in that it is prepared separately: the effervescent mixture containing a carbonate or bicarbonate, citric acid and, if necessary, glycine, sweeteners, perfumes and colorant; the active mixture constituted by tetracylin, complexing amine and, if necessary, vitamin c, as well as aspirin, then joining these three mixtures and transforming them into tablets, granules or effervescent powders. (Machine-translation by Google Translate, not legally binding)