DELTA3-A-nor-androstenes (I or II): (R = lower alkyl or aralkyl; R1, R2 = OH or Oacyl; X = halogen, 9(11)-posn. satd. or epoxy gp.), are anti-androgenics, esp. 11alpha-hydroxy-AD or its mesylate; DELTA3, 9(11)-AD; 9alpha-halo-11beta-hydroxy- or acetoxy-AD; 9beta,11beta-epoxy-AD; 9alpha-fluoro-AT, its di- and tri-acetate; (AD = DELTA3-A-nor-androstone-2,17-dione, AT = the corresp. 2beta,11beta,17beta-triol). Prepd. from the sulphonyl-ester of 11alpha-hydroxy-AD via the DELTA3,9(11)-AD, this treated with AcNHBr and HClO4 in dioxan to 9alpha-bromo- 11beta-hydroxy-AD (also obtained microbiologically), and via the 9beta,11beta-epoxy cpd., to the 9alpha-halo-11beta-hydroxysteroid.
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机译：DELTA3-A-正雄烯基（I或II）：（ R =低级烷基或芳烷基; R1，R2 = OH或Oacyl; X =卤素，9（11）-饱和或环氧环氧）是抗氧化剂-雄激素，特别是。 11α-羟基-AD或其甲磺酸酯; DELTA3，9（11）-AD; 9alpha-halo-11beta-hydroxy-或acetoxy-AD; 9β，11β-环氧-AD; 9alpha-fluoro-AT，其二乙酸盐和三乙酸盐; （AD = DELTA3-A-nor-androstone-2,17-dione，AT =相应的2beta，11beta，17beta-triol）。准备经由DELTA3,9（11）-AD从11alpha-hydroxy-AD的磺酰基酯中，在二恶烷中用AcNHBr和HClO4处理成9alpha-bromo-11beta-hydroxy-AD（也通过微生物学方法），并通过9beta ，11beta-环氧cpd。，变成9alpha-halo-11beta-羟基类固醇。
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