ANTIBIOTIC COMPOSITION CONTAINING CEPHALOSPORIN DERIVATIVES AND NEW CEPHALOSPORIN DERIVATIVES

摘要

1,195,203. Cephalosporin medicines. GLAXO LABORATORIES Ltd. 19 June, 1967 [24 June, 1966]., No. 28522/66. Heading A5B. [Also in Division C2] An antibiotic composition comprises (A) a broad spectrum cephalosporin subject to degradation by a #-lactarmase produced by proteus morgani and (B) a cephalosporin antibiotic resistant to degradation by said #-lactamase whereby said broad spectrum antibiotic is protected against such degradation and its spectrum and/or degree of activity thereby improved. Cephalosporin (A) may be a compound of formula: wherein RSP4/SP is 2-thienyl methyl or D-α-amino- α-phenyl methyl and RSP5/SP is acetate or, in betaine form with the adjacent catboxyl Py+ (where Py is N-pyridyl or substituted N-pyridyl) e.g. cephaloridine. Cephalosporin (B) may be a compound of formula:- or a salt thereof with non-toxic cations, wherein RSP1/SP is (1) a carboxycylic aromatic group containing at least one substituent in an ortho position (2) a 3-aryl-5-methyl-isoxazol-4-yl group or (3) a 1,1-disubstituted aralkyl group; and RSP2/SP is acetate or azide group. The composition may be in the form of an aqueous or oily injection; tablets capsules, aqueous or oily suspensions, solutions, emulsions, syrup or elizirs for oral use; powder or liquid drops, sprays or inhalants; ointments, creams, lotions, paints for topical use; and veterinary preparations e.g. veterinary cerates.