PROCESS FOR PREPARING A NEW POLYMORPHIC FORM OF LINCOMYCIN HYDROCHLIRIDE.

摘要

A process for preparing a new polymorphic form of hncomycin hydrochlonde, the crystals of which are characterized by the X-ray diffraction pattern : 1NTERPLANAR SPACINGS, A 14 02* 10 52 9 40 8 53 6 96 6.19* 5 90 5 55 5 34 5 15 5 01 4 62* 4 48 4 26 4 13 4 C4 3 88 3 67 3 50 3 45 3 28 3 02 2 90 ? 16 2 57 "Mijor peaks which comprises . adding acetone slowiy to an aqueous solution of Itncomycm hydrochlonde at a temperature above about 25C , and separating tnt ciystals of the new polymorphic form ofhncomjcm hydrothloridc thus produced.