19.8 lactone - steroid derivatives and process for their manufacture

摘要

ABSTRACT OF THE DISCLOSUREThere are provided novel 19,8-lactone steroidderivatives having the formula(I)wherein A and B represent 14- or 15-carbon atoms, respectively,which are either linked by a double bond, or which carry an u-or .beta.-oxido or a 14.alpha.- or .beta.-hydroxy group in which case B is amethylene group Y is =O; 3.alpha. or 3.beta.-hydroxy; O-alkyl; or O-acyl;R' is OH, =O or acetoxy, the 5-hydrogen atom is either in the.alpha. or .beta.-position; there is an optional double bond in position4(5); 5(6) and 6(7); and R is selected from the group consist-ing of O-alkyl; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;and CN, wherein alkyl is tetrahydropyranyl, lower alkyl,preferably methyl or ethyl, or a substituted methyl whereinthe substituent is selected from the group consisting of phenyl,halogen, preferably chlorine and bromine, methoxy, CH2=CHand HC?C; acyl represents a group selected from those consistingof acetate, trilower-alkyl acetates wherein the lower alkylgroup is preferably methyl or ethyl, monohalo acetates andtrihalo acetates, preferably wherein the halogen is chlorineand bromine. Several processes for preparing such novel com-pounds are disclosed, which compounds are useful as intermediatesin the preparation of further compounds.