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2-omega-carboxyalkyl) cyclopentanols and (m)ethyl - esters prepn - from cyclopentanone and alkenoic acids or esters
2-omega-carboxyalkyl) cyclopentanols and (m)ethyl - esters prepn - from cyclopentanone and alkenoic acids or esters
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机译:由环戊酮和烯酸或酯制备的2-ω-羧基烷基)环戊醇和(间)乙基酯。
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摘要
Cpds. of formula (I): (where n = 2-17; R is H, Me or Et) are prepd. by reacting CH2=CHCmH2mCOOR (where m = 0-15) with excess cyclopentanone in the presence of an initiator, pref. a cpd. releasing free radicals, pref. at 60-200 degrees C, to give a cpd. (II) of formula: (I); is = O and reducing this to (I), pref. with a complex metal hydride, e.g. NaBH4, at -40 to +40 degrees C. Cpds. (I) and (II) are expected to have pharmacological activity; Cpd (II) n = 6, R=Me is a prostaglandin intermediate.
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