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Optically active (S or R) -β- amino acids and optically active (R or S) -β- production method of amino acid esters, as well as β- amino acid 2-alkoxy ethyl ester and optically active (S or R) -β- amino acid 2 - alkoxy ethyl ester
Optically active (S or R) -β- amino acids and optically active (R or S) -β- production method of amino acid esters, as well as β- amino acid 2-alkoxy ethyl ester and optically active (S or R) -β- amino acid 2 - alkoxy ethyl ester
The presence of a hydrolase, in an organic solvent, and water, formula invention, (I): Wherein, which may have a substituent, represents a heteroaryl group, alkyl, alkenyl, alkynyl, cycloalkyl, araalkyl group, an aryl group, and R 1, R may have a substituent I represent an alkyl group which may have, and characterized by causing a hydrolysis reaction selectively only one enantiomer of a racemic mixture at the indicated β- amino acid esters of the general formula (II): Wherein, R is as defined above, * represents an asymmetric carbon atom, and the general formula -β- amino acid (R or S) optically active at shown, (III): Formula, R 1 and R is as defined above, and represents an asymmetric carbon atom, provided that * has a steric absolute configuration opposite to that of the compound of general formula (II), I to provide a method of manufacturing a -β- amino acid ester (S or R) optically active at shown.
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