3-phenyl-3-(substd-amino)-3,4-dihydro-isocoumarins - and isochromans - as anti hypertensive agents and diuretics

摘要

Cpds. of the formula: (where R is H, CF3 or 1-5C-alkyl or -alkoxy, R1 is H, F, Cl, CF3 1-5C-alkyl or -alkoxy or two R1 together form -O-CH2-O-, R2 is H, F, Cl, CF3 or 1-5C-alkoxy, R3 and R4 are 1-5C alkyl, 2-5C alkenyl or PhCH2 or NR3R4 is 1-pyrrolidinyl, piperidino, 1-azepinyl 1-azocinyl, morpholino, thiomorpholino, or 4-(1-5C)-alkyl-1-piperazinyl, R5 is H or 1-5C alkyl, X is CH2 or CO, at most three of R,R1 and R2 are other than H and two of R, R1 and R2 are h on each ring, R and R2 are not both halogen and two CF3 gps. may not be present on adjacent C-atoms) are prepared by reacting an o-methyl-N-alkylbenzamide Li salt with a di-substd amino propiophenone and ring closing the o- beta-(2.di substd aminoethyl)-beta-hydroxy-phenethyl-N-alkylbenzamide by heating at 100 degrees C.