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N-(3, 4-dihydroxy-beta-phenethyl) amides of amino-acids - - which are renal vasodilators and hypertensives
N-(3, 4-dihydroxy-beta-phenethyl) amides of amino-acids - - which are renal vasodilators and hypertensives
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机译:氨基酸的N-(3,4-二羟基-β-苯乙基)酰胺-是肾血管扩张剂和高血压
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摘要
Title amides of formula (I): (where R is H, lower alkyl, hydroxymethyl, hydroxybenzyl, 2-hydroxyethyl, mercaptomethyl, methylmercaptoethyl, 3-indolylmethyl, 2-carboxyethyl, 3-guanidinopropyl, 4-aminobutyl or 5-imidazolylmentyl) and their acceptable acid addition salts, which can be used for treating renal hypertension and shock, may be prepd. by reacting 3,4-dibenzyloxy-beta-phenethylamine with HOOC-CHR-NH-COOCH2C6H5 and hydrogenating the resulting N-carbobenzoxy cpd. in the presence of methanol and acid.
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