new type prostaglandin compound, their preparation and medicines containing plant

摘要

13,14-Dihydro-15-methyl-prostaglandin derivatives of the formula IMAGE in which M is one of the two groups IMAGE or IMAGE, g is 3, 4 or 5 and n is 2 to 6, as well as mixtures of this compound and the enantiomer thereof, are prepared by acylating all hydroxyl groups of an optically active lactone or a mixture of this lactone and the enantiomer thereof and then separating the resulting epimer mixture chromatographically. Thereafter, the acyl groups are again removed by hydrolysis and the double bond present is hydrogenated. Finally, the product is reduced to the corresponding lactol and the side chain is introduced into the latter by reaction with a Wittig reagent. The free acid obtained is also esterified to give esters. Further, the resulting PFG-like compound is converted to a PGE-like compound, a PGA-like compound or a PGB-like compound. The compounds obtained, as well as their salts and esters, can be used for the same pharmacological purposes as corresponding known prostaglandin derivatives.