analogifremgangsmåde to manufacture of 13 alkyl d homogonadien - 3 - structions.

摘要

D-Homosteroids of the formula IMAGE in which R3 is (H,H) or ( alpha -H, beta -O-acyl), R13 is lower alkyl, R17a beta is H or acyl, R17a alpha is ethynyl, 1-propynyl, vinyl, chloroethynyl, butadienyl or propadienyl, and the dotted line in the A ring indicates an additional C-C bond in the 4,5 or 5(10) position. These D-homosteroids have hormonal activity and can be prepared in a manner known per se starting from the 17-keto-D-homosteroids corresponding to the D-homosteroids of the formula I, on the one hand by reaction of these 17-ketosteroids with an organometallic compound supplying a radical R17a alpha or, on the other hand, by following this reaction by acylation of the resulting 17a beta -hydroxy-D-homosteroid.