analogifremgangsmåde to manufacture of 16 hydroxylated 17alfa - ethynyl - 17beta - hydroxy - 13beta - alkylgona - 4,9,11 - industry - 3 - structions.

摘要

1386440 16-Hydroxy steroids ROUSSEL UCLAF 21 Aug 1972 [26 Aug 1971] 31600/74 Divided out of 1386439 Heading C2U The invention comprises compounds of formulµ (wherein R is C 1-3 alkyl and K is a ketal group); and their preparation from 3-alkoxy-16- hydroxy - 17 - ketal - 13 - alkylgona - 1,3,5(10)- trienes by Birch reduction to give 3-alkoxy-16- hydroxy - 17 - ketal - 13 - alkylgona - 2,5(10)- dienes, followed by hydrolysis with an organic acid to give 3-oxo-16-hydroxy-17-ketal-13-alkylgon-5(10)-enes, followed by dehydrogenation (e.g. with pyridinium bromide perbromide) to give compounds V, followed by acid hydrolysis to give compounds VI, followed by selective ketalization to give compounds VII, optionally followed by replacement of one ketal group K by another.