1513874 1 - Ethyl - 3a - (substituted phenyl)- decahydroisoquinolines ELI LILLY & CO 3 June 1975 [7 June 1974] 23868/75 Heading C2C Novel compounds of the Formula I wherein RSP1/SP is O-(C 1-3 )alkyl, hydroxy or -OCO(C 1-3 )alkyl and pharmaceutically acceptable salts thereof may be prepared by reacting a compound VII wherein RSP11/SP is OH or -O-(C 1-3 ) alkyl with an ethyl halide and if desired converting the product I wherein RSP1/SP is OH into the corresponding compound wherein RSP1/SP is -O-(C 1-3 )alkyl or -OCO(C 1-3 )alkyl and/or forming salts thereof and/or resolving isomers thereof. The intermediates VII are described and claimed in Application No. 1693/78. The cis isomers of a precursor 1-methyl-3a-(m-methoxyphenyl - 1,2,3,3a,4,5,6,7,7a,8 - decahydro isoquinoline are described and claimed in Application No. 1694/78. Pharmaceutical compositions of the compounds I with the usual excipients are analgetic agonistic and analgetic antagonistic when administered parenterally or orally.
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