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pyroglutamylforeningar with antidepressant effect, and still for their framstellning
pyroglutamylforeningar with antidepressant effect, and still for their framstellning
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机译:焦谷氨酰增强剂具有抗抑郁作用,并且仍对它们有帮助
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摘要
Novel pyroglutamyl compounds of the formula I IMAGE in which X denotes an optionally branched alkyl radical having 2 to 6 carbon atoms or an optionally branched alkyl radical having 2 to 6 carbon atoms which is either substituted in the alpha -position by a carbamoyl group or in the omega -position by a carbamoyl group or a carboxyl group, are prepared by reaction of a pyroglutamic acid, which is optionally substituted on the nitrogen by a benzyloxycarbonyl radical, or of a reactive derivative thereof with a primary amine which introduces the group X and subsequent removal of possible carboxyl protective groups. The novel compounds are useful therapeutics for the treatment of psychic disorders, in particular of depressions.
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