A procedure to increase vincristine performance. (Machine-translation by Google Translate, not legally binding)

摘要

A procedure to increase the yield of vincristine when vincristine is separated from the drug of vinca rosea l., in which the enriched mixture of alkaloid dimers obtained from the drug vinca rosea l., with also having N-desmethyl-vimblastine native, or the acid addition salt of said dimeric alkaloid mixture, is formylated at room temperature to transform the N-demethyl-vimblastine into vincristine; the reaction mixture is poured into about five times its volume of water, with cooling, taking care that the temperature of the aqueous solution does not exceed 10º c; it adjusts to the ph of the acidic aqueous solution; it is extracted with an organic solvent; the phases are separated, and the organic phases are dried and evaporated under reduced pressure; the dry residue is dissolved in a solvent and subjected to chromatography by collecting the fractions containing vincristine, which can optionally be converted into its acid addition salts. (Machine-translation by Google Translate, not legally binding)