Dibromo-dihydro-lysergic acid prepn. - by bromination of 9,10-dihydro-lysergic acid in inert solvent, pref. glacial alcoholic or propionic acid

摘要

New 2, 13-dibromo-9,10-dihydrolysergic acid (I) is prepd. by brominating 9,10-dihydrolyseric acid (II) in an inert solvent, pref. glacial acetic acid or propionic acid, and opt. converting the prod. to a salt with a base or acid. Bromination is carried out with elementary bromine, pyridine hydrobromide perbromie; trimethylphenyl ammonium tribromide or pyrrolidone-(2)-hydrotribromide.