Tyramine prepn. by decarboxylation of tyrosine - and purificn. via the oxalate salt

摘要

Tyramine (I) and its salts are prepd. by (a) decarboxylating 1-tyrosine at high temp. in diphenyl ether as heat-transfer medium; (b) treating the crude product with oxalic acid; (c) suspending the resulting (I) oxalate in a lower alcohol and introducing HCl gas to form the hydrochloride or adding another acid to form another sa and opt. (d) converting the resulting salt into (I). The prod. has hypertensive, peripheral vasoconstricting and uterus-contracting activity. The process gives good yields (e.g. 60%) of (I) pure enough for pharmaceutical purposes, and can be operated on a technical scale.