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Method of preparation of carboxamides of the oxo - 1,2 benzothiazine preferably cannot, or substantially dioxides 1,1 - - -
Method of preparation of carboxamides of the oxo - 1,2 benzothiazine preferably cannot, or substantially dioxides 1,1 - - -
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机译:氧代-1,2-苯并噻嗪的羧酰胺的制备方法优选不能或基本上不能被氧化的1,2,1---
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摘要
Disclosed herein is an improved process for the production of carboxamides of 3,4-dihydro-oxo-1,2-benzothiazine-1,1-dioxides. Said process comprises contacting either a 4-alkoxy-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide or a 3-alkoxy-1,2-benzothiazine-4-carboxylic acid-1,1-dioxide with an amine followed by cleavage of the ether moiety with an appropriate reagent such as hydrogen bromide to produce a carboxanilide with previously disclosed pharmaceutical value as a non-steroidal anti inflammatory agent. The alkoxy-benzothiazine carboxylic acids are themselves novel compounds and valuable synthetic intermediates.
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