Sepharose type polysaccharides with amino-acid, pref glycine, gps - useful as non-specific immunity adjuvants for vaccines

摘要

Polysaccharides of the 'Sepharose' type having -NH-(CH2)n-COOH gps. (where n=1,2 or 3). The polysaccharides are esp. those having beta-D-galactopyranose gps. and 3,6-dianhydro-alpha-L-galactopyranose gps; the Beta-D-galactopyranose gps. are in corresponding pairs joined to each other in 1,3 posns. and the 3,6-dianhydro-alpha-L-galactopyranose gps. are also pref. in corresponding pairs joined 1,4. They are used as non-specific immunity adjuvants esp. for vaccines e.g. where the vaccine antigens have only weak immunogenic capacity. They may also be injected separately after administration of the vaccine. The polysaccharides have good stability and are free from toxicity and are injected as aqs. dispersions (sterilised at 120 degrees C) at doses of 50-5000 (pref. 500-1000) mg. per unit dose of vaccine, used for treatment of viral or bacterial disease.