Stereoselective introduction of tetracyclines hydroxyl group at 12(a) position in synthesis of tetracyclines

摘要

In the synthesis of tetracyclines, a critical step is the stereospecific or stereoselective introduction of a hydroxyl group at the C-12(a) position, a novel method for the introduction of this critical hydroxy group is disclosed. Additionally, synthetic procedures for obtaining tetracycline precursors are discussed.