Synthesis and Neuroprotective Activity of Novel C4, C7 Derivatives in Tetracycline Series

摘要

Since the discovery of the titracycline in 1953,numerous natural and semesynthetic tetracyclines have been reported with broad spectrum amtibacterial activity,Doxycycline 1 and 2 are semisynthetic second-generation tetracyclines that exert anti-in-