PROCESS FOR MANUFACTURE OF INTERMEDIATES OF SUBSTITUTED OMEGAAPENTANOLPROSTAGLANDINS

摘要

1456514 Phosphonates PFIZER Inc 7 Nov 1973 [8 Nov 1972] 22858/76 Divided out of 1456512 Heading C2P Novel phosphonates of the formula wherein Ar is phenyl, halophenyl, trifluoromethylphenyl, biphenylyl, C 1-6 alkylphenyl, C 1-6 alkoxyphenyl, 3,4 - dimethoxyphenyl, 3,4,5 - trimethoxyphenyl, 3,4 - methylenedioxyphenyl, or 1- or 2-naphthyl; R is C 1-6 alkyl; and m and n are 0 to 3 with the proviso that the sum of m and n does not exceed 3 are prepared by reacting esters of the formula wherein RSP1/SP is C 1-6 alkyl, with the appropriate dialkyl methylphosphonates.