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analogifremgangsmåde for the manufacture of lithium - 21 - m - sulphobenzoate 424b of 6alfa - methylprednisolone.
analogifremgangsmåde for the manufacture of lithium - 21 - m - sulphobenzoate 424b of 6alfa - methylprednisolone.
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机译:用于制造6α-甲基强的松龙中21 m的磺基苯甲酸锂424b的类似物。
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摘要
1375357 Corticoid 21-sulphobenzoate ROUSSEL UCLAF 21 May 1973 [19 May 1972] 24013/73 Heading C2U The invention comprises 6-methylprednisolone 21-(m-sulphobenzoate) and its alkali metal salts. The salts are prepared from the corresponding 21-methanesulphonate by reaction with a di-(alkali metal) m-sulphobenzoate in the presence of an N-alkyl-amide (e.g. DMF), and may be converted to the free acid by passing over an acidic ion-exchange resin. The free acid may thereafter be resalified. 6-Methylprednisolone 21-methanesulphonate is prepared from the free 21-ol by reaction with mesyl chloride. Antiinflammatory compositions for oral, parenteral, topical and rectal administration comprise a compound of the invention and a carrier.
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